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KMID : 0869619880050010056
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Journal of Korean Society of Hospital Pharmacists
1988 Volume.5 No. 1 p.56 ~ p.58
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The Effect of Smoking Withdrawal on the Elimination Half-lives of Theophylline in Healthy Smokers
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金美那
申院均/申鉉澤/趙成石/金辰圭
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Abstract
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Theophylline serum concentrations were measured at 2, 4, and 8 hours after single dose administration of aminophylline plain tablet in both healthy smokers (n=3) and non-smokers(n=3) to observe the effect of smoking withdrawals on the hepatic clearance of theophylline. Sampling procedures were repeated every week in smokers and every other week in non-smokers for 4 weeks of study period. Elimination half-lives of theophylline in smokers were dramatically increased during two weeks and gradually recovered to the mean serum half-life of non-smokers (mean±SD＝8.74±1.57 hours) at 4 th week. These results suggest that smoking effect on the metabolic clearance of theophylline may diminish within month when smoking habit withdrawn in smokers. We would recommend more careful monitoring of serum theophylline concentrations in patients with acute respiratory distress with smoking history, especially during initial first month of hospitalization.
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KEYWORD
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